What is SPRAVATO® (esketamine) CIII Nasal Spray?

SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth to treat:

  • Adults with treatment-resistant depression (TRD)

  •  Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions


SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe or effective as an anesthetic medicine.


It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO®.

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Get to Know SPRAVATO®

Greater reduction of depression symptoms at four weeks (compared to those who received a placebo and oral antidepressant)

After you take SPRAVATO, a healthcare professional will monitor you for at least two hours during the observation period for possible side effects

After 16 weeks of therapy, those patients who stayed on SPRAVATO did better than those who stopped therapy

Studied in adults with treatment-resistant depression and taken with a daily oral antidepressant

Nasal Spray you self-administer under the supervision of a healthcare professional

Tell your doctor if you have a history of drug or alcohol abuse


Preparing for Treatment

You'll need to plan for rides to and from the certified SPRAVATO® treatment center. Because of possible side effects affecting mental alertness and motor coordination, you won't be able to drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.

You may want to bring a book, a relaxing playlist or another form of entertainment for the session because your healthcare provider will monitor you for at least two hours after treatment.

Some patients taking SPRAVATO® may experience nausea or vomiting. You should avoid eating two hours before, and drinking liquids 30 minutes before, taking SPRAVATO®.

If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before taking SPRAVATO®.